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CRISPR-Cas 9 Gene Editing in Hematopoietic Stem Cells: Risks of Genomic Instability and Cancer Development


Research Question: How does CRISPR-Cas9 editing affect the long-term genomic stability of hematopoietic stem cells, and what evidence shows it can cause large-scale chromosomal damag...
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CRISPR/Cas-9 Gene Editing: Making Porcine Xenotransplantation a Viable Treatment Option for End Stage Renal Disease


End Stage Renal Disease (ESRD): From 2000 to 2019, the incident count of newly diagnosed patients with ESRD (the final stage of Chronic Kidney Disease) has drastically increased from 94,...
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GGTA1 Editing in Porcine Cardiac Xenotransplantation


Xenotransplantation, the process of transplanting tissues or organs of one species to another species, has recently received much attention on behalf of the University of Maryland Medicin...
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Evolutionary Journey from Microbes to Gut Colonization: Understanding the Success of Fecal Microbiota Transplantations


Hypothesis: This literature review investigates the evolutionary journey of microbes from choanoflagellates to the colonization of the human gut to understand the success of fecal microbi...
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Exploring the Gut-Brain Axis


Hippocrates, over 2,000 years ago, attributed disease origins to the gastrointestinal system [1]. While these thoughts were undoubtedly ahead of their time, scientists now realize how acc...
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Culturomics: Essentials to a Successful Bacterial Culture


Research Question: How can scientists systematically study the gut microbiome bacteria strains using culturomics and genomics?